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Anim Nutr 4(1):1116 Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ (2009) Hyperhomocysteinemia increases -amyloid by enhancing expression of -secretase and phosphorylation of amyloid precursor protein in rat brain

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However, while HLMs provide one of the most convenient ways to assess CYP-mediated metabolism they hardly predict in vivo metabolism of phase II metabolism other than glucuronidation, or the combination of both phase I and II metabolism ( To summarize, 2D cell models of cell lines are the easiest to handle and most reproducible models for in vitro toxico-metabolomic studies